DPYSL3 antibody (C-Term)

Catalog No. ABIN347041

This Rabbit Polyclonal antibody specifically detects DPYSL3 in WB, ELISA and IHC. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for DPYSL3 antibody (C-Term) (ABIN347041)

Target: DPYSL3 (Dihydropyrimidinase-Like 3 (DPYSL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYSL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DPYSL3 Antibody

Binding Specificity: C-Term

Specificity: Reacts with 65 kDa CRMP-4 from human rat and mouse

Cross-Reactivity (Details): Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5.

Purification: Antiserum

Immunogen: A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
-IHC : 1/500 - WB :1/2 000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

References for anti-DPYSL3 antibody (ABIN347041)

Blasco, Bernard-Marissal, Vourch, Guettard, Sunyach, Augereau, Khederchah, Mouzat, Antar, Gordon, Veyrat-Durebex, Besson, Andersen, Salachas, Meininger, Camu, Pettmann, Andres, Corcia: "A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS." in: Human mutation, Vol. 34, Issue 7, pp. 953-60, (2013) (PubMed).

Bretin, Reibel, Charrier, Maus-Moatti, Auvergnon, Thevenoux, Glowinski, Rogemond, Prémont, Honnorat, Gauchy: "Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain." in: The Journal of comparative neurology, Vol. 486, Issue 1, pp. 1-17, (2005) (PubMed).

Ricard, Rogemond, Charrier, Aguera, Bagnard, Belin, Thomasset, Honnorat: "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 18, pp. 7203-14, (2001) (PubMed).

Honnorat, Byk, Kusters, Aguera, Ricard, Rogemond, Quach, Aunis, Sobel, Mattei, Kolattukudy, Belin, Antoine: "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes." in: The European journal of neuroscience, Vol. 11, Issue 12, pp. 4226-32, (2000) (PubMed).

Balin, Loewy, Appelt: "Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease." in: Methods in enzymology, Vol. 309, pp. 172-86, (1999) (PubMed).

Target Details for DPYSL3

Target: DPYSL3 (Dihydropyrimidinase-Like 3 (DPYSL3))

Alternative Name: Collapsin Response Mediator Protein 4 (CRMP-4)

Background: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration

UniProt: Q14195