TTC3 antibody (N-Term)

Catalog No. ABIN347721

This anti-TTC3 antibody is a Rabbit Polyclonal antibody detecting TTC3 in ELISA, WB and IF. Suitable for Human.

Quick Overview for TTC3 antibody (N-Term) (ABIN347721)

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTC3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TTC3 Antibody

Binding Specificity: N-Term

Specificity: Reacts with human E3 ubiquitin-protein ligase TTC3

Purification: Antiserum

Immunogen: Synthetic peptide derived from Cter domain of human TTC3

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IF(1:100 - 1:500) WB(1:500 - 1:5000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

Target Details for TTC3

Target: TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))

Alternative Name: E3 ubiquitin-protein ligase TTC3

Background: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

UniProt: P53804