Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

NOS1 antibody (C-Term)

NOS1 Reactivity: Human WB, IHC Host: Goat Polyclonal unconjugated
Catalog No. ABIN350524
  • Target See all NOS1 Antibodies
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Binding Specificity
    • 22
    • 15
    • 13
    • 9
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 122
    • 87
    • 59
    • 15
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 126
    • 24
    • 2
    • 1
    Goat
    Clonality
    • 122
    • 31
    Polyclonal
    Conjugate
    • 73
    • 17
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This NOS1 antibody is un-conjugated
    Application
    • 117
    • 56
    • 47
    • 29
    • 27
    • 26
    • 25
    • 20
    • 15
    • 8
    • 7
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purpose
    Goat antibody to nNOS
    Specificity
    Specific for nNOS
    Cross-Reactivity
    Guinea Pig, Human, Mouse, Rabbit, Rat
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG purified. Sterilised UV-C irradiated acidified to pH 3.5 then neutralised
    Immunogen
    Synthetic peptides from the c-terminal region of human nNOS conjugated to blue carrier protein was used as the antigen.
    Isotype
    IgG
    Top Product
    Discover our top product NOS1 Primary Antibody
  • Application Notes
    IHC WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Alternative Name
    nNOS (NOS1 Products)
    Background
    FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. CATALYTIC ACTIVITY: L-arginine + n NADPH + m O2 = citrulline + nitric oxide + n NADP+. ENZYME REGULATION: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP. SUBCELLULAR LOCATION: Cell membrane sarcolemma, Peripheral membrane protein. Cell projection dendritic spine. Note=In skeletal muscle it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons enriched in dendritic spines. TISSUE SPECIFICITY: Isoform N-NOS-1 is expressed in brain and colorectum. Found in the Auerbach's plexus of the enteric nervous system. Isoform PNNOS is expressed in the penis urethra prostate and skeletal muscle and coexists with the cerebellar nnos in the pelvic plexus bladder and liver and is detectable in the cerebellum.
    UniProt
    P29476
    Pathways
    Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
You are here:
Support