Trpl antibody (4th Cytoplasmic Loop)

Catalog No. ABIN351177

This anti-Trpl antibody is a Rabbit Polyclonal antibody detecting Trpl in IHC and WB. Suitable for Drosophila melanogaster.

Quick Overview for Trpl antibody (4th Cytoplasmic Loop) (ABIN351177)

Target: Trpl (Transient Receptor Potential-Like (Trpl))

Reactivity: Drosophila melanogaster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Trpl antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-Trpl Antibody

Binding Specificity: 4th Cytoplasmic Loop

Purpose: Rabbit antibody to drosophila TRPL

Specificity: Specific for TRPL.

Cross-Reactivity: Drosophila melanogaster

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from 4th cytoplasmic loop of drosophila TRPL (Transient receptor potential like protein) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotype: IgG

Application Details

Application Notes: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Trpl

Target: Trpl (Transient Receptor Potential-Like (Trpl))

Alternative Name: TRPL

Background: FUNCTION: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with trp-gamma. Activated by fatty acids metabolic stress inositols and GTP-binding proteins. SUBUNIT: Forms heteromultimers with trp-gamma and to a lower extent with trp. Interacts with FKBP59 in vivo and is found in the inaD signaling complex. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Note: In the dark there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions.

UniProt: P48994

Pathways: Sensory Perception of Sound, Phototransduction