Vesicle-Associated Membrane Protein 2-Like (LOC102558953) (AA 10-60) antibody

Catalog No. ABIN7698533

This Rabbit Polyclonal antibody specifically detects in IHC and WB. It exhibits reactivity toward Human.

Quick Overview for Vesicle-Associated Membrane Protein 2-Like (LOC102558953) (AA 10-60) antibody (ABIN7698533)

Target: Vesicle-Associated Membrane Protein 2-Like (LOC102558953)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details

Binding Specificity: AA 10-60

Purpose: Rabbit antibody to VAMP 2 1 (10-60)

Specificity: Specific for VAMP2 and VAMP1.

Cross-Reactivity: Human, Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from AA 10-60 of human VAMP2 conjugated to blue carrier protein was used as the antigen. The VAMP2 peptide shares 93% shared identity with VAMP1. The peptide is homologous in many other species including rat mouse and xenopus.

Isotype: IgG

Application Details

Application Notes: IHC WB. A working concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details

Target: Vesicle-Associated Membrane Protein 2-Like (LOC102558953)

Alternative Name: VAMP 2 1

Background: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs syntaxins and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin synaptosomal-associated protein 25 kD and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane. SUBCELLULAR LOCATION: Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane, Single-pass type IV membrane protein. Cell junction synapse synaptosome. Note: Neuronal synaptic vesicles.

UniProt: P63027