Vesicle-Associated Membrane Protein 2-Like (LOC102558953) (AA 10-60) antibody
LOC102558953
Reactivity: Human
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Vesicle-Associated Membrane Protein 2-Like (LOC102558953)
- Binding Specificity
- AA 10-60
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purpose
- Rabbit antibody to VAMP 2 1 (10-60)
- Specificity
- Specific for VAMP2 and VAMP1.
- Cross-Reactivity
- Human, Mouse, Rat
- Cross-Reactivity (Details)
- Other species not yet tested.
- Purification
- IgG
- Immunogen
- A synthetic peptide from AA 10-60 of human VAMP2 conjugated to blue carrier protein was used as the antigen. The VAMP2 peptide shares 93% shared identity with VAMP1. The peptide is homologous in many other species including rat mouse and xenopus.
- Isotype
- IgG
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- Application Notes
- IHC WB. A working concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
- Handling Advice
- Avoid freeze and thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Vesicle-Associated Membrane Protein 2-Like (LOC102558953)
- Alternative Name
- VAMP 2 1
- Background
- The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs syntaxins and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin synaptosomal-associated protein 25 kD and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane. SUBCELLULAR LOCATION: Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane, Single-pass type IV membrane protein. Cell junction synapse synaptosome. Note: Neuronal synaptic vesicles.
- UniProt
- P63027
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