KLF4 antibody (N-Term)

Catalog No. ABIN357863

The Rabbit Polyclonal anti-KLF4 antibody has been validated for IHC (p) and EIA. It is suitable to detect KLF4 in samples from Human.

Quick Overview for KLF4 antibody (N-Term) (ABIN357863)

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-KLF4 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects KLF4 (N-term).

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human KLF4.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Immunohistchemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for KLF4

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Alternative Name: KLF4

Background: Krüppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.Synonyms: EZF, Epithelial zinc finger protein EZF, GKL, Gut-enriched krueppel-like factor, Krueppel-like factor 4

Molecular Weight: 50945 Da

Gene ID: 9314, 9606

UniProt: O43474

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance