MAPK11 antibody (Middle Region)

Catalog No. ABIN359418

This anti-MAPK11 antibody is a Rabbit Polyclonal antibody detecting MAPK11 in WB, IHC (p) and EIA. Suitable for Human and Mouse.

Quick Overview for MAPK11 antibody (Middle Region) (ABIN359418)

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-MAPK11 Antibody

Binding Specificity: Middle Region

Specificity: This antibody detects MAPK11 at center.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human MAPK11.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for MAPK11

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Alternative Name: MAP Kinase p38 beta / MAPK11

Background: MAPK11 is a Ser/Thr kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. It preferentially phosphorylates transcription factor ATF2. This protein is activated by phosphorylation on threonine and tyrosine by MKK6, and is inhibited by pyridinyl-imidazole related compounds. Highest expression levels are in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.Synonyms: Mitogen-activated protein kinase 11, PRKM11, SAPK2, Stress-activated protein kinase 2, p38-2

Molecular Weight: 42132 Da

Gene ID: 5600, 5874

UniProt: Q15759

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Response to Water Deprivation, Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Hepatitis C, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins