DCXR antibody (Middle Region)

Catalog No. ABIN359606

The Rabbit Polyclonal anti-DCXR antibody has been validated for WB, IHC (p), FACS and EIA. It is suitable to detect DCXR in samples from Human and Mouse.

Quick Overview for DCXR antibody (Middle Region) (ABIN359606)

Target: DCXR (Dicarbonyl/L-Xylulose Reductase (DCXR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCXR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Product Details anti-DCXR Antibody

Binding Specificity: Middle Region

Specificity: This antibody recognizes Human and Mouse DCXR. Other species not tested.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of Human DCXR.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000
Western blotting: 1/50 - 1/100
Immunohistochemistry on Paraffin Sections: 1/50-1/100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for DCXR

Target: DCXR (Dicarbonyl/L-Xylulose Reductase (DCXR))

Alternative Name: L-Xylulose Reductase

Background: DCXR is an enzyme that has both diacetyl reductase and L-xylulose reductase activities. Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. Cellular Location: Membrane, Peripheral membrane protein (By similarity). Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). Tissue Location: Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.Synonyms: Carbonyl reductase II, DCXR, Dicarbonyl/L-xylulose reductase, Kidney dicarbonyl reductase, P34H, Sperm surface protein P34H, XR

Molecular Weight: 25913 Da (calculated)

Gene ID: 51181, 9606

UniProt: Q7Z4W1

Pathways: Glycosaminoglycan Metabolic Process, Monocarboxylic Acid Catabolic Process