ICAM1 antibody (AA 510-514)

Catalog No. ABIN362684

This Rabbit Polyclonal antibody specifically detects ICAM1 in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for ICAM1 antibody (AA 510-514) (ABIN362684)

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICAM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ICAM1 Antibody

Binding Specificity: AA 510-514

Specificity: The antibody detects endogenous level of total ICAM-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogen: Peptide sequence around AA 510-514 (K-K-Y-R-L) derived from Human ICAM-1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Application Details

Application Notes: Western blotting: 1:500-1:1000  

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

References for anti-ICAM1 antibody (ABIN362684)

Wang, Zhang, Yan, Zhao, Zhou, Wang, Lu, Zhang: "Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK." in: Free radical biology & medicine, Vol. 50, Issue 9, pp. 1094-106, (2011) (PubMed).

Ould-yahoui, Tremblay, Sbai, Ferhat, Bernard, Charrat, Gueye, Lim, Brew, Risso, Dive, Khrestchatisky, Rivera: "A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons." in: PLoS ONE, Vol. 4, Issue 12, pp. e8289, (2009) (PubMed).

Sbai, Ould-Yahoui, Ferhat, Gueye, Bernard, Charrat, Mehanna, Risso, Chauvin, Fenouillet, Rivera, Khrestchatisky: "Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes." in: Glia, Vol. 58, Issue 3, pp. 344-66, (2009) (PubMed).

Target Details for ICAM1

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Alternative Name: ICAM-1

Background: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Molecular Weight: 92 kDa

NCBI Accession: NP_000192

UniProt: P05362

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling