Claudin 3 antibody (C-Term)

Catalog No. ABIN372578

The Rabbit Polyclonal anti-Claudin 3 antibody is suitable to detect Claudin 3 in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for Claudin 3 antibody (C-Term) (ABIN372578)

Target: Claudin 3 (CLDN3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Claudin 3 Antibody

Binding Specificity: C-Term

Specificity: Specific to Claudin 3 (CLDN3).
Cellular Localization: Cell membrane and cytoplasmic.

Cross-Reactivity (Details): Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.

Purification: Immunoaffinity Chromatography.

Immunogen: A synthetic peptide derived from the C-terminus of Mouse Claudin-3.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM PBS, pH 7.6 containing 15 mM Sodium Azide as preservative and 0.2 % BSA,40 % Glycerol as stabilizers.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for Claudin 3

Target: Claudin 3 (CLDN3)

Alternative Name: Claudin-3 / CLDN3

Background: Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact, made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. The protein encoded by this intronless Claudin 3 gene is also a low affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis related protein found in rat.Synonyms: C7orf1, CPE-R2, CPE-Receptor 2, CPETR2, Clostridium perfringens enterotoxin receptor 2, RVP1

Gene ID: 1365

NCBI Accession: NP_001297

UniProt: O15551

Pathways: Hepatitis C