GABBR1 antibody (pSer923)

Catalog No. ABIN372645

The Rabbit Polyclonal anti-GABBR1 antibody (ABIN372645) specifically detects GABBR1 in WB. The antibody is reactive with Human, Rat, Mouse, Cow and Non-Human Primate samples.

Quick Overview for GABBR1 antibody (pSer923) (ABIN372645)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reactivity: Human, Rat, Mouse, Cow, Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABBR1 Antibody

Binding Specificity: pSer923

Specificity: Specific for ~102k GABAB R1 phosphorylated at Ser923. Immunolabeling of the GABAB R1 band is completely blocked by lambda-phosphatase treatment.

Cross-Reactivity (Details): Species reactivity (expected):Human, Bovine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephospho-peptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1

Isotype: IgG

Application Details

Application Notes: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C.

Target Details for GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Alternative Name: GABBR1

Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.Synonyms: GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, Gb1

Gene ID: 81657

NCBI Accession: NP_112290

UniProt: Q9Z0U4

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process