GRM1a / GRM5 antibody (C-Term)

Catalog No. ABIN372670

This Rabbit Polyclonal antibody specifically detects GRM1a / GRM5 in WB and IHC (fro). It exhibits reactivity toward Rat, Human and Mouse.

Quick Overview for GRM1a / GRM5 antibody (C-Term) (ABIN372670)

Target: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM1a / GRM5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GRM1a / GRM5 Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogen: Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.

Isotype: IgG

Application Details

Application Notes: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C.

Target Details for GRM1a / GRM5

Target: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Alternative Name: mGluR5/1a

Background: The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).Synonyms: GRM1A, GRM5, MGLUR1a, MGLUR5, Metabotropic Glutamate Receptor 5/1a