RPH3A antibody (C-Term)

Catalog No. ABIN372709

This Rabbit Polyclonal antibody specifically detects RPH3A in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow and Non-Human Primate.

Quick Overview for RPH3A antibody (C-Term) (ABIN372709)

Target: RPH3A (Rabphilin 3A (RPH3A))

Reactivity: Human, Mouse, Rat, Dog, Cow, Non-Human Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPH3A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RPH3A Antibody

Binding Specificity: C-Term

Specificity: This antibody recognizes the ~82k Rabphilin-3A protein.

Cross-Reactivity (Details): Species reactivity (expected):Human, Bovine, Canine and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region of Rabphilin-3A.

Isotype: IgG

Application Details

Application Notes: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at-20 °C.

Target Details for RPH3A

Target: RPH3A (Rabphilin 3A (RPH3A))

Alternative Name: Rabphilin-3A / RPH3A

Background: Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994,Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington's disease (Smith et al., 2005). Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995,Foletti and Scheller, 2001).Synonyms: Exophilin 1, Exophilin-1, KIAA0985, Rabphilin 3A

Gene ID: 171039

NCBI Accession: NP_598202

UniProt: P47709

Pathways: Synaptic Vesicle Exocytosis