SECISBP2 antibody (Internal Region)

Catalog No. ABIN374739

The Goat Polyclonal anti-SECISBP2 antibody (ABIN374739) specifically detects SECISBP2 in WB, IF, IP, EIA and IHC (p). The antibody is reactive with Human, Cow, Dog and Pig samples.

Quick Overview for SECISBP2 antibody (Internal Region) (ABIN374739)

Target: SECISBP2 (SECIS Binding Protein 2 (SECISBP2))

Reactivity: Human, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This SECISBP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SECISBP2 Antibody

Binding Specificity: Internal Region

Sequence: C-KERQERKQRL QEN

Specificity: This antibody recognizes SBP2.

Cross-Reactivity (Details): Species reactivity (expected):Canine, Pig, Cow.
Species reactivity (tested):Human.

Purification: Affinity Chromatpography

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_076982.3.

Application Details

Application Notes: Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL. Immunohistochemistry on paraffin sections: 3 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SECISBP2

Target: SECISBP2 (SECIS Binding Protein 2 (SECISBP2))

Alternative Name: SECISBP2

Background: SECISBP2 is an RNA binding protein that interacts with the Sec insertion sequence (SECIS) element in selenoprotein mRNAs. The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. Mutations in the SECISBP2 gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.Synonyms: SBP2, SECIS-binding protein 2, Selenocysteine insertion sequence-binding protein 2

Gene ID: 79048

NCBI Accession: NP_076982

UniProt: Q96T21