BMP6 antibody (Biotin)

Catalog No. ABIN380078

The Mouse Monoclonal anti-BMP6 antibody is suitable to detect BMP6 in samples from Rat. It has been validated for IHC and IHC (fro).

Quick Overview for BMP6 antibody (Biotin) (ABIN380078)

Target: BMP6 (Bone Morphogenetic Protein 6 (BMP6))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This BMP6 antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: Morph-6-1

Product Details anti-BMP6 Antibody (Biotin)

Specificity: Bone morphogenic protein 6. Pre-incubation of morph-6.1 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the antibody to tissue sections. Pre-incubation with other amino- terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as an irrelevant peptide does not inhibit specific tissue staining. Antigen distribution: Tissue sections: Positive staining can be observed in embryonic and adult central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in perinuclear region of most Schwann cells which form the myelin sheath. However, some Schwann cells were negative for morph-6.1. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by Desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative with morph-6.1. Specificity: Rat: Bone morphogenic Protein-6 (BMP-6) Synonyms are: vgr-1 (vegetal related) or DVR-6 (decapentaplegic vegetal related). Other species: phylogenetically highly conserved (human positive)

Purification: Affinity purified

Immunogen: Aminoterminal synthetic peptide 1-29-KLh

Type of Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Approved: IHC, IHC-Fr (1:100 - 1:200)

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.5 mL distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS  pH 7.2, 5 mg/mL BSA, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C.

Target Details for BMP6

Target: BMP6 (Bone Morphogenetic Protein 6 (BMP6))

Alternative Name: BMP6 / BMP-6

Background: Name/Gene ID: BMP6
Family: TGF beta

Synonyms: BMP6, BMP-6, Bone morphogenetic protein 6, VG-1-related protein, VGR1, VG-1-R, VGR, Vg1, Vg1-related sequence, VGR-1

Gene ID: 654

UniProt: P22004

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process