PRDM2 antibody (AA 1-347)

Catalog No. ABIN387783

Cited in 2+ publications. The Mouse Monoclonal anti-PRDM2 antibody (Clone 33AT1045) (ABIN387783) specifically detects PRDM2 in WB and ChIP. The antibody is reactive with Human and Mouse samples.

Quick Overview for PRDM2 antibody (AA 1-347) (ABIN387783)

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRDM2 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Clone: 33AT1045

Product Details anti-PRDM2 Antibody

Binding Specificity: AA 1-347

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

Isotype: IgG1

Application Details

Application Notes: CHIP: 1:100. CHIP: 1:100. CHIP: 1:100. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PRDM2 antibody (ABIN387783)

Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression." in: Journal of hematology & oncology, Vol. 2, pp. 28, (2009) (PubMed).

Carling, Kim, Yang, Gu, Zhang, Huang: "A histone methyltransferase is required for maximal response to female sex hormones." in: Molecular and cellular biology, Vol. 24, Issue 16, pp. 7032-42, (2004) (PubMed).

Target Details for PRDM2

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Alternative Name: PRDM2 (RIZ1)

Background: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 188915

Gene ID: 7799

NCBI Accession: NP_001007258, NP_001129082, NP_036363, NP_056950

UniProt: Q13029