Dnmt2 antibody (AA 346-375)

Catalog No. ABIN387859

This Rabbit Polyclonal antibody specifically detects Dnmt2 in WB and IHC (p). It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for Dnmt2 antibody (AA 346-375) (ABIN387859)

Target: Dnmt2 (TRDMT1) (tRNA Aspartic Acid Methyltransferase 1 (TRDMT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dnmt2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1850

Product Details anti-Dnmt2 Antibody

Binding Specificity: AA 346-375

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Dnmt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human Dnmt2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Dnmt2 antibody (ABIN387859)

Lee, Jang, Benoit, Hoque, Califano, Trink, Sidransky, Mao, Moon: "Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome." in: Genomics, Vol. 96, Issue 2, pp. 67-72, (2010) (PubMed).

Target Details for Dnmt2

Target: Dnmt2 (TRDMT1) (tRNA Aspartic Acid Methyltransferase 1 (TRDMT1))

Alternative Name: Dnmt2

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 44597

Gene ID: 1787

NCBI Accession: NP_004403

UniProt: O14717