BMP6 antibody (N-Term)

Catalog No. ABIN388456

This Rabbit Polyclonal antibody specifically detects BMP6 in WB and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for BMP6 antibody (N-Term) (ABIN388456)

Target: BMP6 (Bone Morphogenetic Protein 6 (BMP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB01862

Product Details anti-BMP6 Antibody

Binding Specificity: AA 25-55, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human Bmp6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-BMP6 antibody (ABIN388456)

Crews, Adame, Patrick, Delaney, Pham, Rockenstein, Hansen, Masliah: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, (2010) (PubMed).

Target Details for BMP6

Target: BMP6 (Bone Morphogenetic Protein 6 (BMP6))

Alternative Name: Bmp6

Background: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

Molecular Weight: 57226

Gene ID: 654

NCBI Accession: NP_001709

UniProt: P22004

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process