ACO2 antibody (AA 438-467)

Catalog No. ABIN388648

This Rabbit Polyclonal antibody specifically detects ACO2 in WB and IHC (p). It exhibits reactivity toward Human and Rat and has been mentioned in 5+ publications.

Quick Overview for ACO2 antibody (AA 438-467) (ABIN388648)

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACO2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB9338

Product Details anti-ACO2 Antibody

Binding Specificity: AA 438-467

Predicted Reactivity: B, M, Pig

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ACO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human ACO2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ACO2 antibody (ABIN388648)

Ruiz, Bégou, Launay, Ranea-Robles, Bianchi, López-Erauskin, Morató, Guilera, Petit, Vaurs-Barriere, Guéret-Gonthier, Bonnet-Dupeyron, Fourcade, Auwerx, Boespflug-Tanguy, Pujol: "Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease." in: Brain pathology (Zurich, Switzerland), (2017) (PubMed).

Navarro, Botella, Metzendorf, Lind, Schneuwly: "Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich?s ataxia." in: Free radical biology & medicine, Vol. 85, pp. 71-82, (2015) (PubMed).

Fernandes, Uytterhoeven, Kuenen, Wang, Slabbaert, Swerts, Kasprowicz, Aerts, Verstreken: "Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration." in: The Journal of cell biology, Vol. 207, Issue 4, pp. 453-62, (2014) (PubMed).

Maity, Bindu, Dey, Goyal, Alam, Pal, Mitra, Bandyopadhyay et al.: "Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel ..." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3058-68, (2009) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." in: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).

Target Details for ACO2

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Alternative Name: ACO2

Background: ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Molecular Weight: 85425

Gene ID: 50

NCBI Accession: NP_001089

UniProt: Q99798