BMPR1A antibody (N-Term)

Catalog No. ABIN388732

This Rabbit Polyclonal antibody specifically detects BMPR1A in WB and IHC (p). It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for BMPR1A antibody (N-Term) (ABIN388732)

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB01766

Product Details anti-BMPR1A Antibody

Binding Specificity: AA 30-60, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-60 amino acids from the N-terminal region of human BMPR1A.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-BMPR1A antibody (ABIN388732)

Peng, Mukhopadhyay, Jarrett, Yoshikawa, Kessler: "BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 48, pp. 17211-24, (2012) (PubMed).

Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).

Mukhopadhyay, McGuire, Peng, Kessler: "Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation." in: Development (Cambridge, England), Vol. 136, Issue 15, pp. 2633-42, (2009) (PubMed).

Target Details for BMPR1A

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Alternative Name: BMPR1A

Background: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Molecular Weight: 60198

Gene ID: 657

NCBI Accession: NP_004320

UniProt: P36894

Pathways: Stem Cell Maintenance