MYT1 antibody (pThr495)

Catalog No. ABIN389599

This Rabbit Polyclonal antibody specifically detects MYT1 in WB, IHC (p) and DB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for MYT1 antibody (pThr495) (ABIN389599)

Target: MYT1 (Myelin Transcription Factor 1 (MYT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Clone: RB7898

Product Details anti-MYT1 Antibody

Binding Specificity: pThr495

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MYT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T495 of human MYT1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MYT1 antibody (ABIN389599)

Mac?rek, Lindqvist, Lim, Lampson, Klompmaker, Freire, Clouin, Taylor, Yaffe, Medema: "Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery." in: Nature, Vol. 455, Issue 7209, pp. 119-23, (2008) (PubMed).

Target Details for MYT1

Target: MYT1 (Myelin Transcription Factor 1 (MYT1))

Alternative Name: MYT1

Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Molecular Weight: 54521

Gene ID: 9088

NCBI Accession: NP_001245379, NP_001245380, NP_004194, NP_872629

UniProt: Q99640

Pathways: Cell Division Cycle