Claudin 1 antibody (AA 40-82)

Catalog No. ABIN390289

This Rabbit Polyclonal antibody specifically detects Claudin 1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Claudin 1 antibody (AA 40-82) (ABIN390289)

Target: Claudin 1 (CLDN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB13129

Product Details anti-Claudin 1 Antibody

Binding Specificity: AA 40-82

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Claudin 1(CLDN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-82 amino acids from human Claudin 1(CLDN1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Claudin 1

Target: Claudin 1 (CLDN1)

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Molecular Weight: 22744

Gene ID: 9076

NCBI Accession: NP_066924

UniProt: O95832

Pathways: Cell-Cell Junction Organization, Hepatitis C