WNT4 antibody (C-Term)

Catalog No. ABIN390635

The Rabbit Polyclonal anti-WNT4 antibody has been validated for WB and IHC (p). It is suitable to detect WNT4 in samples from Human. There is 1 publication available.

Quick Overview for WNT4 antibody (C-Term) (ABIN390635)

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNT4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB19966

Product Details anti-WNT4 Antibody

Binding Specificity: AA 242-269, C-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This WNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the C-terminal region of human WNT4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-WNT4 antibody (ABIN390635)

Beyer, Schramm, Akhmetshina, Dees, Kireva, Gelse, Sonnylal, de Crombrugghe, Taketo, Distler, Schett, Distler: "?-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis." in: Annals of the rheumatic diseases, Vol. 71, Issue 5, pp. 761-7, (2012) (PubMed).

Target Details for WNT4

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Alternative Name: WNT4

Background: The WNT family consists of secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT4 is a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. It play a concerted role in both the control of female development and the prevention of testes formation.

Molecular Weight: 39052

Gene ID: 54361

NCBI Accession: NP_110388

UniProt: P56705

Pathways: WNT Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cell-Cell Junction Organization, Tube Formation