WNT4 antibody (AA 122-351)

Catalog No. ABIN6150246

Product Details anti-WNT4 Antibody

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Binding Specificity: AA 122-351

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNT4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FAVTRACSSG ELEKCGCDRT VHGVSPQGFQ WSGCSDNIAY GVAFSQSFVD VRERSKGASS SRALMNLHNN EAGRKAILTH MRVECKCHGV SGSCEVKTCW RAVPPFRQVG HALKEKFDGA TEVEPRRVGS SRALVPRNAQ FKPHTDEDLV YLEPSPDFCE QDMRSGVLGT RGRTCNKTSK AIDGCELLCC GRGFHTAQVE LAERCSCKFH WCCFVKCRQC QRLVELHTCR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 122-351 of human WNT4 (NP_110388.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-WNT4 antibody (ABIN6150246)

Zhang, Mehmood, Jiang, Yao, Iqbal, Waqas, Rehman, Li, Shen, Li: "Effect of tetramethyl thiuram disulfide (thiram) in relation to tibial dyschondroplasia in chickens." in: Environmental science and pollution research international, Vol. 25, Issue 28, pp. 28264-28274, (2019) (PubMed).

Target Details for WNT4

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Alternative Name: WNT4 (WNT4 Products)

Synonyms: CG4698 antibody, DWnt-4 antibody, DWnt4 antibody, Dm DWnt4 antibody, Dmel\\CG4698 antibody, Dwnt4 antibody, Wnt antibody, Wnt-4 antibody, anon-EST:Liang-2.4 antibody, clone 2.4 antibody, wnt-4 antibody, wnt4 antibody, SERKAL antibody, WNT-4 antibody, Xwnt4 antibody, xwnt-4 antibody, zgc:136737 antibody, Wnt family member 4 antibody, Wnt oncogene analog 4 antibody, wingless-type MMTV integration site family, member 4 antibody, wingless-type MMTV integration site family member 4 S homeolog antibody, wingless-type MMTV integration site family, member 4a antibody, WNT4 antibody, Wnt4 antibody, wnt4.S antibody, wnt4a antibody

Background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.,WNT4,SERKAL,WNT-4,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Tumor suppressors,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Stem Cells,WNT4

Molecular Weight: 32 kDa/39 kDa

Gene ID: 54361

UniProt: P56705

Pathways: WNT Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cell-Cell Junction Organization, Tube Formation