LATS2 antibody (AA 228-258)

Catalog No. ABIN391034

There is 1 publication for this product available. The Rabbit Polyclonal anti-LATS2 antibody is suitable to detect LATS2 in samples from Human. It has been validated for IHC (p).

Quick Overview for LATS2 antibody (AA 228-258) (ABIN391034)

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LATS2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3032

Product Details anti-LATS2 Antibody

Binding Specificity: AA 228-258

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-258 amino acids from the Central region of human LATS2.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LATS2 antibody (ABIN391034)

Yamashita, Yamamoto, Mimori, Nishida, Takahashi, Haraguchi, Tanaka, Shibata, Sekimoto, Ishii, Doki, Mori: "MicroRNA-372 is associated with poor prognosis in colorectal cancer." in: Oncology, Vol. 82, Issue 4, pp. 205-12, (2012) (PubMed).

Target Details for LATS2

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Alternative Name: LATS2

Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Molecular Weight: 120136

Gene ID: 26524

NCBI Accession: NP_055387

UniProt: Q9NRM7