CKMT1 antibody (N-Term)

Catalog No. ABIN391091

The Rabbit Polyclonal anti-CKMT1 antibody is suitable to detect CKMT1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for CKMT1 antibody (N-Term) (ABIN391091)

Target: CKMT1 (Creatine Kinase, Mitochondrial 1, Ubiquitous (CKMT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5397-5398

Product Details anti-CKMT1 Antibody

Binding Specificity: AA 55-84, N-Term

Predicted Reactivity: B, Pig, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CKMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human CKMT1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CKMT1

Target: CKMT1 (Creatine Kinase, Mitochondrial 1, Ubiquitous (CKMT1))

Background: Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase.

Molecular Weight: 47037

Gene ID: 548596

NCBI Accession: NP_001015001, NP_066270

UniProt: P12532