LRRK1 antibody (C-Term)

Catalog No. ABIN391141

This Rabbit Polyclonal antibody specifically detects LRRK1 in WB. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for LRRK1 antibody (C-Term) (ABIN391141)

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB6531

Product Details anti-LRRK1 Antibody

Binding Specificity: AA 1981-2015, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This LRRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1981-2015 amino acids from the C-terminal region of human LRRK1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LRRK1 antibody (ABIN391141)

Toyofuku, Morimoto, Sasawatari, Kumanogoh: "Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation." in: Molecular and cellular biology, Vol. 35, Issue 17, pp. 3044-58, (2015) (PubMed).

Target Details for LRRK1

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Alternative Name: LRRK1

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Molecular Weight: 225393

Gene ID: 79705

NCBI Accession: NP_078928

UniProt: Q38SD2