GUCY1A1 antibody (N-Term)

Catalog No. ABIN391201

This Rabbit Polyclonal antibody specifically detects GUCY1A1 in WB and IHC (p). It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for GUCY1A1 antibody (N-Term) (ABIN391201)

Target: GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB07757

Product Details anti-GUCY1A1 Antibody

Binding Specificity: AA 269-300, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Guanylyl Cyclase alpha 1 (GUCY1A3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-300 amino acids from the N-terminal region of human Guanylyl Cyclase alpha 1 (GUCY1A3).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GUCY1A1 antibody (ABIN391201)

Hedlund, Karlsson, Osborn, Ludwig, Isacson: "Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection." in: Brain : a journal of neurology, Vol. 133, Issue Pt 8, pp. 2313-30, (2010) (PubMed).

Target Details for GUCY1A1

Target: GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha (GUCY1A1))

Alternative Name: Guanylyl Cyclase alpha 1 (GUCY1A3)

Background: Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.

Molecular Weight: 77452

Gene ID: 2982

NCBI Accession: NP_000847, NP_001124154, NP_001124155, NP_001124156, NP_001124159, NP_001243378

UniProt: Q02108

Pathways: Myometrial Relaxation and Contraction