CAMKII gamma antibody (C-Term)

Catalog No. ABIN391313

The Rabbit Polyclonal anti-CAMKII gamma antibody has been validated for WB and IHC (p). It is suitable to detect CAMKII gamma in samples from Human and Mouse. There is 1 publication available.

Quick Overview for CAMKII gamma antibody (C-Term) (ABIN391313)

Target: CAMKII gamma (CAMK2G) (Calcium/calmodulin-Dependent Protein Kinase II gamma (CAMK2G))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMKII gamma antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1246

Product Details anti-CAMKII gamma Antibody

Binding Specificity: AA 309-338, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CAMK2G (CAMK2 gamma) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the C-terminal region of human CAMK2G (CAMK2 gamma).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:500-1000. WB: 1:500. WB: 1:2000. IHC-P: 1:50~100. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CAMKII gamma antibody (ABIN391313)

Jiang, Wu, Lu, Zhang, Yu, Gan, Wu, Xu, Zheng, Zhang, Xu, Ma, Gan, Huang, Yu, Huang, Xu: "Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a." in: Oncotarget, Vol. 8, Issue 43, pp. 75050-75064, (2017) (PubMed).

Target Details for CAMKII gamma

Target: CAMKII gamma (CAMK2G) (Calcium/calmodulin-Dependent Protein Kinase II gamma (CAMK2G))

Alternative Name: CAMK2G (CAMK2 gamma)

Background: CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.

Molecular Weight: 62607

Gene ID: 818

NCBI Accession: NP_001213, NP_751909, NP_751913

UniProt: Q13555

Pathways: WNT Signaling, Interferon-gamma Pathway, Hormone Transport, Myometrial Relaxation and Contraction, Regulation of long-term Neuronal Synaptic Plasticity