RND3 antibody (AA 133-165)

Catalog No. ABIN392162

The Rabbit Polyclonal anti-RND3 antibody has been validated for WB and IHC (p). It is suitable to detect RND3 in samples from Human, Mouse and Rat.

Quick Overview for RND3 antibody (AA 133-165) (ABIN392162)

Target: RND3 (rho Family GTPase 3 (RND3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RND3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB14500

Product Details anti-RND3 Antibody

Binding Specificity: AA 133-165

Predicted Reactivity: Pig

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ARHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the Central region of human ARHE.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for RND3

Target: RND3 (rho Family GTPase 3 (RND3))

Alternative Name: ARHE

Background: Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925), GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855), and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]).

Molecular Weight: 27368

Gene ID: 390

NCBI Accession: NP_001241667, NP_005159

UniProt: P61587