MAP3K6 antibody (C-Term)

Catalog No. ABIN392411

The Rabbit Polyclonal anti-MAP3K6 antibody has been validated for WB and IHC (p). It is suitable to detect MAP3K6 in samples from Human and Mouse. There is 1 publication available.

Quick Overview for MAP3K6 antibody (C-Term) (ABIN392411)

Target: MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6 (MAP3K6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB0946

Product Details anti-MAP3K6 Antibody

Binding Specificity: AA 1028-1058, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MEKK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1028-1058 amino acids from the C-terminal region of human MEKK6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MAP3K6 antibody (ABIN392411)

Han, Oh, Kang, Kim, Seo, Kim, Park, Kim: "Protein profiling in human sera for identification of potential lung cancer biomarkers using antibody microarray." in: Proteomics, Vol. 9, Issue 24, pp. 5544-52, (2009) (PubMed).

Target Details for MAP3K6

Target: MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6 (MAP3K6))

Alternative Name: MEKK6

Background: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK6 activates the JNK, but not ERK or p38 kinase pathways.

Molecular Weight: 142596

Gene ID: 9064

NCBI Accession: NP_004663

UniProt: O95382