TIMELESS antibody (N-Term)

Catalog No. ABIN410144

The Rabbit Polyclonal anti-TIMELESS antibody has been validated for WB, ELISA and IHC. It is suitable to detect TIMELESS in samples from Human.

Quick Overview for TIMELESS antibody (N-Term) (ABIN410144)

Target: TIMELESS (Timeless Homolog (TIMELESS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMELESS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TIMELESS Antibody

Binding Specificity: N-Term

Specificity: Reacts with human 138 kDa protein

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): Cross reacts with proteins from mouse, rat and other species.

Purification: Antiserum

Immunogen: Synthetic peptide derived from Nter domain of human hTIM protein

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200 - WB : 1/100 to 1/1 000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

Target Details for TIMELESS

Target: TIMELESS (Timeless Homolog (TIMELESS))

Alternative Name: Protein Timeless Homolog (hTIM)

Background: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism