ELISA: Use of this Mucin-16/CA125 antibody at a concentration of 0.125 ng/mL canrecognize coated 5 international unit of CA125/well. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Reconstitution
Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL.
Buffer
0.01 M PBS, pH 7.0 without preservatives.
Preservative
Without preservative
Storage
-20 °C
Storage Comment
Store the antibody at -20 °C. After reconstitution, aliquot and store at -20 °C. Shelf life: one year from despatch.
Mucin16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller subunits being described by some investigators.Synonyms: CA 125, CA-125, MUC-16, MUC16, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125