CRP antibody

Catalog No. ABIN452590

This Mouse Monoclonal antibody specifically detects CRP in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for CRP antibody (ABIN452590)

Target: CRP (C-Reactive Protein (CRP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: S5G1

Product Details anti-CRP Antibody

Specificity: Reactive with Human CRP in Immunoblot and ELISA

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: PTX1, C Reactive Protein, Pentraxin-related

Purification: Affinity Chromatography on Protein G.

Immunogen: Purified CRP from human pleural fluid.

Isotype: IgG1

Application Details

Application Notes: ELISAImmunoblotting (Western).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS, pH 7.2 without preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CRP

Target: CRP (C-Reactive Protein (CRP))

Background: C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.Synonyms: C Reactive Protein, PTX1, Pentraxin-related

Gene ID: 1401

UniProt: P02741

Pathways: Carbohydrate Homeostasis