GNAS antibody (Middle Region)

Catalog No. ABIN453062

The Rabbit Polyclonal anti-GNAS antibody is suitable to detect GNAS in samples from Human. It has been validated for WB and EIA.

Quick Overview for GNAS antibody (Middle Region) (ABIN453062)

Target: GNAS (GNAS Complex Locus (GNAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNAS antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GNAS Antibody

Binding Specificity: Middle Region

Specificity: This antibody detects GNAS at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human GNAS

Application Details

Application Notes: Western blot: 1: 100 - 1: 500. ELISA: 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Alternative Name: GNAS1 / XLalphas

Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms.Synonyms: Adenylate cyclase-stimulating G alpha protein, Extra large alphas protein, G protein alpha XLas, Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Molecular Weight: 111025 Da

Gene ID: 2778

NCBI Accession: NP_536350

UniProt: Q5JWF2

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis