ADRA2B antibody (AA 349-378)

Catalog No. ABIN453503

The Rabbit Polyclonal anti-ADRA2B antibody has been validated for WB, IF, FACS, IHC (p) and EIA. It is suitable to detect ADRA2B in samples from Human.

Quick Overview for ADRA2B antibody (AA 349-378) (ABIN453503)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-ADRA2B Antibody

Binding Specificity: AA 349-378

Specificity: This antibody recognizes Alpha-2B adrenergic receptor.

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 349~378 amino acids from the Center region of Human ADRA2B. Genename: ADRA2B

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Alternative Name: alpha-2B Adrenergic Receptor

Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor

Gene ID: 151

NCBI Accession: NP_000673

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process