COQ3 antibody (Middle Region)

Catalog No. ABIN453581

The Rabbit Polyclonal anti-COQ3 antibody has been validated for WB and EIA. It is suitable to detect COQ3 in samples from Human.

Quick Overview for COQ3 antibody (Middle Region) (ABIN453581)

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-COQ3 Antibody

Binding Specificity: Middle Region

Specificity: This antibody reacts to COQ3.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human COQ3

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for COQ3

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Alternative Name: COQ3

Background: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. COQ3 is an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.Synonyms: 3, 4-dihydroxy-5-hexaprenylbenzoate methyltransferase, DHHB methyltransferase, DHHB-MTase, Dihydroxyhexaprenylbenzoate methyltransferase, mitochondrial Hexaprenyldihydroxybenzoate methyltransferase

Gene ID: 51805

NCBI Accession: NP_059117

UniProt: Q9NZJ6

Pathways: Methionine Biosynthetic Process