CD3 antibody

Catalog No. ABIN487433

The Hamster Monoclonal anti-CD3 antibody is suitable to detect CD3 in samples from Mouse.

Quick Overview for CD3 antibody (ABIN487433)

Target: CD3

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CD3 antibody is un-conjugated

Application: Please inquire

Clone: 145-2C11

Product Details anti-CD3 Antibody

Specificity: This antibody reacts with mouse CD3 (epsilon subunit). It is commonly used as a phenotypic marker for mouse T cells.

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Characteristics: Synonyms: T3/Leu-4, T-cell surface glycoprotein CD3, T-cell surface antigen T3/Leu-4

Purification: Protein A affinity chromatography

Endotoxin Level: Low Endotoxin

Immunogen: Mouse BM10-37 cytotoxic T lymphocytes

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL (> 95% pure by SDS-PAGE)

Buffer: Phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized. Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD3

Target: CD3

Alternative Name: CD3

Background: CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4

Gene ID: 12501

UniProt: P22646

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway