GLA antibody (C-Term)

Catalog No. ABIN4886604

This anti-GLA antibody is a Rabbit Polyclonal antibody detecting GLA in WB. Suitable for Mouse and Rat.

Quick Overview for GLA antibody (C-Term) (ABIN4886604)

Target: GLA (Galactosidase, alpha (GLA))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GLA Antibody

Binding Specificity: AA 218-275, C-Term

Purpose: Anti-Galactosidase alpha/Gla Antibody Picoband®

Sequence: DIQYYCNHWR NFDDVYDSWE SIKNILSWTV VYQKEIVEVA

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Galactosidase alpha/Gla Antibody Picoband® (ABIN4886604). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Gla, different from the related human sequence by fifteen amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat
1. "Entrez Gene: GLA galactosidase, alpha". 2. Calhoun DH, Bishop DF, Bernstein HS, Quinn M, Hantzopoulos P, Desnick RJ (1985). "Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A". Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7364-8. 3. Keating GM (October 2012). "Agalsidase alfa: a review of its use in the management of Fabry disease". BioDrugs. 26 (5): 335-54.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for GLA

Target: GLA (Galactosidase, alpha (GLA))

Alternative Name: Gla

Background:

Synonyms: Alpha-galactosidase A,3.2.1.22 ,Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Melibiase,Gla,Ags,

Background: Alpha-galactosidase is a glycoside hydrolase enzyme that encoded by the GLA gene. This gene is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Molecular Weight: 49 kDa

Gene ID: 11605

UniProt: P51569

Pathways: SARS-CoV-2 Protein Interactome