PRNP antibody (C-Term)

Catalog No. ABIN4889437

This Mouse Monoclonal antibody specifically detects PRNP in WB, ELISA and IF. It exhibits reactivity toward Human, Rat, Cow and Sheep.

Quick Overview for PRNP antibody (C-Term) (ABIN4889437)

Target: PRNP (Prion Protein (PRNP))

Reactivity: Human, Rat, Cow, Sheep

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRNP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 4H7

Product Details anti-PRNP Antibody

Binding Specificity: C-Term

Specificity: Reacts with full sequence PrP protein of brain tissue from different species (bovin, human, sheep, rat

Cross-Reactivity: Sheep (Ovine), Rat (Rattus)

Cross-Reactivity (Details): .) Cross reacts with brain tissue from different species (bovin, human, sheep, rat ...)

Purification: Purified (protein A)

Immunogen: A 15 residue synthetic peptide derived from C-terminal domain of human PrP protein

Isotype: IgG2a kappa

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IF(1:200 - 1:1000) WB(1:200 - 1:1000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Concentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M, sucrose 2 %

Storage: 4 °C/-20 °C

Storage Comment: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 24 months

Target Details for PRNP

Target: PRNP (Prion Protein (PRNP))

Alternative Name: Prion Protein (PrP)

Background: PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like type 1 (HDL1) and kuru in humans, scrapie in sheep and goat, bovine spongiform encephalopathy (BSE) in cattle.

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation