TFF1 antibody

Catalog No. ABIN4901698

This Mouse Monoclonal antibody specifically detects TFF1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TFF1 antibody (ABIN4901698)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TFF1 Antibody

Purpose: HP-1α is a protein encoded by the CBX5 gene which is approximately 22,2 kDa. HP-1α is localised to the nucleus. It is involved in chromatin regulation and acetylation, E2F mediated regulation of DNA replication and aurora B signalling. It is a highly conserved non-histone protein that falls under the heterochromatin protein family. It has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins. It is also involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. HP-1α is expressed in the liver, nervous system, kidney, eye and intestine. Mutations in the CBX5 gene may result in Reynolds syndrome. STJ98895 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous HP-1α protein.

Specificity: The antibody detects endogenous HP-1α protein.

Characteristics: Mouse Monoclonal to HP-1α.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Recombinant peptide derived from HP-1alpha.

Application Details

Application Notes: WB 1:500-2000
ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: HP-1alpha

Molecular Weight: 22kDa

Gene ID: 23468

UniProt: P45973

Pathways: EGFR Signaling Pathway