CD3 antibody

Catalog No. ABIN490172

Product Details anti-CD3 Antibody

Target: CD3

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD3 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Blocking Antibody (Inhibition)

Specificity: The mouse monoclonal antibody OKT3 recognizes the CD3 antigen of the TCR/CD3 complex on mature human T cells. This antibody, also known as Orthoclone OKT3 or Muromonab-CD3, has been extensively used as a drug for therapy of acute, glucocorticoid resistant rejection of allogenic renal, heart and liver transplants. It has also been investigated for use in treating T-cell acute lymphoblastic leukemia. HLDA VI, WS Code T6T-R3.

Purification: Protein G purified

Immunogen:

Type of Immunogen: Native protein

Clone: OKT3

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, Func, IHC, IHC-Fr, Inhb

Usage: Flow Cytometry: Recommended dilution - 1 μg/mL. Functional Application: counteracting both generation and function of effector T cells.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 15 mM sodium azide,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for CD3

Target: CD3

Alternative Name: CD3 (CD3 Products)

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway