CTNNB1 antibody
Quick Overview for CTNNB1 antibody (ABIN4903403)
Target
See all CTNNB1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Characteristics
- β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
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Purification
- Affinity purification
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Immunogen
- A synthetic peptide of human CTNNB1.
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Isotype
- IgG
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anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (N-Term) antibody
KO Validated CTNNB1 Reactivity: Human WB, IHC, IF, FACS, IHC (p), IP, ICC, IHC (fro), ChIP, CUT&RUN, IHC (wm) Host: Rabbit Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (N-Term) antibodyCTNNB1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 692-721), (C-Term) antibodyCTNNB1 Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB41124 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781) antibodyCTNNB1 Reactivity: Human WB, IHC, ELISA, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 78-106), (N-Term) antibodyCTNNB1 Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB41155 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyKO Validated CTNNB1 Reactivity: Human WB, IHC, IF, FACS Host: Mouse Monoclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibodyKO Validated CTNNB1 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Monoclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 1-100) antibodyCTNNB1 Reactivity: Human, Mouse WB, IHC, ELISA, FACS Host: Mouse Monoclonal 7C5A2 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 632-781) antibodyCTNNB1 Reactivity: Human, Mouse, Rat, Monkey WB, IHC, ELISA, FACS Host: Mouse Monoclonal 5B6E9 unconjugated
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 682-781) antibodyCTNNB1 Reactivity: Human WB, ELISA, IF, PLA, RNAi Host: Mouse Monoclonal 1C9 unconjugated
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Application Notes
- WB 1:500-1:2000 , IHC 1:50-1:100
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C.
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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Alternative Name
- CTNNB1
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Gene ID
- 1499
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UniProt
- P35222
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Pathways
- WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Target
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