CR1L antibody (AA 51-150)

Catalog No. ABIN4908340

This Rabbit Polyclonal antibody specifically detects CR1L in WB, IF (cc), IF (p), IHC (fro), ELISA, IHC (p) and ICC. It exhibits reactivity toward Mouse.

Quick Overview for CR1L antibody (AA 51-150) (ABIN4908340)

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CR1L antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details anti-CR1L Antibody

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Crry

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Alternative Name: Crry

Background:

Synonyms: Mcp, Crry, mCRY, Complement component receptor 1-like protein, Complement regulatory protein Crry, Protein p65, Cr1l, Cry

Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.

Gene ID: 12946

UniProt: Q64735

Pathways: Complement System