SNX6 antibody

Catalog No. ABIN4914189

This anti-SNX6 antibody is a Mouse Monoclonal antibody detecting SNX6 in WB. Suitable for Human.

Quick Overview for SNX6 antibody (ABIN4914189)

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNX6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 5T6

Product Details anti-SNX6 Antibody

Cross-Reactivity: Human

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This SNX6 monoclonal antibody is generated from mouse immunized with SNX6 recombinant protein.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Alternative Name: SNX6

Background:

Synonyms: TFAF2, MSTP010, Sorting nexin-6, TRAF4-associated factor 2, SNX6

Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

Gene ID: 58533

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway