BAFF antibody

Catalog No. ABIN4949453

This anti-BAFF antibody is a Mouse Monoclonal antibody detecting BAFF in FACS and IF. Suitable for Human.

Quick Overview for BAFF antibody (ABIN4949453)

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAFF antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: C257-1638

Product Details anti-BAFF Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant human BAFF protein was used as the immunogen for this BAFF antibody.

Isotype: IgG1

Application Details

Application Notes: Titering of the BAFF antibody may be required for optimal performance.\. FACS: 0.5-1 μg/million cells,IF: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in sterile PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: BAFF antibody with azide can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Alternative Name: BAFF / BLyS

Background: BAFF/BLyS/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31  kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response