BIK antibody (AA 1-123)

Catalog No. ABIN4950330

This Rabbit Polyclonal antibody specifically detects BIK in WB, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for BIK antibody (AA 1-123) (ABIN4950330)

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-BIK Antibody

Binding Specificity: AA 1-123

Purification: Antigen affinity

Immunogen: Amino acids 1-123 of human BIK were used as the immunogen for the BIK antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BIK antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the BIK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for BIK

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Alternative Name: BIK / BCL2-interacting killer

Background: Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. This gene is mapped to 22q13.31. The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

UniProt: Q13323

Pathways: Positive Regulation of Endopeptidase Activity