Ceruloplasmin antibody (AA 20-258)

Catalog No. ABIN4950633

This Rabbit Polyclonal antibody specifically detects Ceruloplasmin in WB and IHC (p). It exhibits reactivity toward Rat and Mouse.

Quick Overview for Ceruloplasmin antibody (AA 20-258) (ABIN4950633)

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ceruloplasmin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Ceruloplasmin Antibody

Binding Specificity: AA 20-258

Purification: Antigen affinity

Immunogen: Amino acids 20-258 of mouse Ceruloplasmin were used as the immunogen for the CP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CP antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Ceruloplasmin

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Alternative Name: Ceruloplasmin / CP

Background: Ceruloplasmin (or Caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. It is mapped to 3q23-q25. The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

UniProt: Q61147

Pathways: Transition Metal Ion Homeostasis