FAS antibody

Catalog No. ABIN4953250

The Mouse Monoclonal anti-FAS antibody has been validated for WB. It is suitable to detect FAS in samples from Human and Rat.

Quick Overview for FAS antibody (ABIN4953250)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 8C1-B9-F12

Product Details anti-FAS Antibody

Purification: Protein G affinity

Immunogen: A human recombinant protein was used as the immunogen for this Fas antibody.

Isotype: IgG2b

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Storage: -20 °C

Storage Comment: Store the Fas antibody at -20°C.

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: Fas / CD95

Background: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity