ASCL1 antibody (AA 63-90)

Catalog No. ABIN3029829

This anti-ASCL1 antibody is a Rabbit Polyclonal antibody detecting ASCL1 in WB and ELISA. Suitable for Human.

Quick Overview for ASCL1 antibody (AA 63-90) (ABIN3029829)

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASCL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ASCL1 Antibody

Binding Specificity: AA 63-90

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 63-90 from the human protein was used as the immunogen for this MASH1 / ASCL1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ASCL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ASCL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Alternative Name: ASCL1 (MASH1)

Background: This gene encodes 'Achaete scute complex homolog like 1' (ASCL1) or 'Mammalian achaete scute complex homolog 1' (MASH1), a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

UniProt: P50553

Pathways: Dopaminergic Neurogenesis